TERMIS 2021 | Healing bone defects with 3D scaffolds and biomimetic film

Charlotte Garot, CEA Grenoble, Grenoble, France, describes research on 3D printed scaffolds combined with 2D osteoinductive coatings to repair bone defects that cannot heal by themselves. Bone autografts require several surgeries and patients may have a limited selection of bone suitable for grafting. A personalized, 3D printed scaffold with a 2D film that mimics the extracellular matrix can stimulate bone growth by releasing bone morphogenetic protein 2 (BMP-2). Initial studies in sheep models have demonstrated promising efficacy, with a lower dose of BMP-2 needed than in current clinical settings. This interview took place at the 6th World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS 2021).