Bruce Levine, PhD, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, offers some of his highlights from the International Society for Cell & Gene Therapy (ISCT) Annual Meeting 2021. Dr Levine praises the success of the meeting’s virtual platform and the Presidential Plenary, which integrated the scientific, quality and regulatory and commercialization pillars. In addition, he considers the evolution of how the field looks at and better understands different cell types and therapies, including RNA and extracellular vesicles. This interview took place during the ISCT Annual Meeting 2021.