Bruce Levine, PhD, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, describes recent approvals and developments within the advanced therapy space, including the FDA approval of ciltacabtagene autoleucel (cilta-cel), a chimeric antigen receptor (CAR) T-cell therapy, in patients with relapsed/refractory multiple myeloma. Dr Levine additionally highlights developments in tumor-infiltrating lymphocytes (TILs), as well the need to focus on Chemistry, Manufacturing, and Control (CMC) standards within the regulatory process. This interview took place at Advanced Therapies Week 2022.