ICLE 2022 | Moving CAR T-cell therapies to earlier lines of therapy in multiple myeloma

Angela Krackhard, MD, PhD, Technical University of Munich, Munich, Germany, comments on the impact of ciltacabtagene autoleucel (cilta-cel) in the multiple myeloma treatment landscape. Cilta-cel is chimeric antigen receptor (CAR) T-cell therapy with two recognition epitopes that target B-cell maturation antigen (BCMA) and had displayed encouraging results for patients with relapsed/refractory multiple myeloma, especially in those who progress from proteosome inhibitors and anti-CD38 antibodies. It additionally is being assessed in earlier settings, especially due to the heterogeneity of the disease. This interview took place at the International Conference on Lymphocyte Engineering (ICLE) 2022.