Volumetric muscle loss (VML) is the loss of skeletal muscle and associated tissue and may result in amputation. Suradip Das, PhD, University of Pennsylvania, Philadelphia, PA, describes the role of neurons in providing tissue-engineered therapies for volumetric muscle loss (VML). Aligned nanofiber sheets cultured with myocytes and motor neurons have demonstrated efficacy in mouse models. Innervation of the engineered tissue enhanced muscle stem cell proliferation and further research is required to successfully implement the findings on a larger scale. This interview took place at the 6th World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS 2021).
Dr Das reports that the concept of Innervation in engineering artificial tissues and organs is protected by PCT application – PCT/US2019/060585.