Renier J. Brentjens, MD, PhD, Memorial Sloan-Kettering Cancer Center, New York, NY, discusses novel CAR designs aimed to improve the efficacy of CAR T-cell recipients, including the development of armored CAR T-cells able to further penetrate malignancies. This interview was recorded via an online conference call with The Video Journal of Hematological Oncology (VJHemOnc)