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ISCT 2021 | The importance of clinical registries & biospecimen analysis in orthobiologics

Nicolas Piuzzi, MD, Cleveland Clinic, Cleveland, OH, provides an overview of the current landscape of cellular therapies in orthopedics. Key evidence-based orthopedic cellular therapies currently being used in clinical practice include the treatment of avascular necrosis and osteoarthritis. Given current challenges around the reproducibility of orthopedic research, Dr Piuzzi proposes that in order to drive the translation of novel cell-based therapies to the clinic, more research involving large prospective cohorts and clinical registries is needed, in order to combine patient outcome data with biospecimen analysis. This interview took place during the International Society for Cell & Gene Therapy (ISCT) Annual Meeting 2021.