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ICLE 2022 | Direct detection and isolation of CAR cells from patient samples

Saskia Rösch, PhD, Miltenyi Biotec, Bergisch Gladbach, Germany, discusses strategies to isolate and identify chimeric antigen receptor (CAR) from patient samples for the purposes of quality control. Dr Rösch outlines a CAR detection agent that finds active CARs by detecting CD19, CD22, CD33, and B-cell maturation antigen (BCMA) in the product, as well as measure their transduction rate. Monitoring the efficacy of CAR T-cell therapies can additionally be carried out by assessing metabolome of CAR T-cells. This interview took place at the International Conference on Lymphocyte Engineering (ICLE) 2022.