John DiPersio, MD, PhD, of Washington University, St. Louis, MO, outlines the next questions in CAR-based therapies and new approaches to improving the efficacy of CAR T-cells including generating CAR T-cells that can target multiple antigens, as well as improving the persistence of CAR T-cells in vivo. This interview was recorded via an online conference call with The Video Journal of Regenerative Medicine (VJRegenMed).