Yan Zhang, PhD, Mission Bio, San Francisco, CA, provides an overview of the Tapestri Platform, a system that incorporates single-cell multi-omics technology, which enables the monitoring of intracellular changes within a single cell. A two-step microfluidic workflow simultaneously isolates and analyzes DNA and proteins in single cells, followed by cell barcoding and targeted multiplex PCR. Dr Zhang additionally highlights the importance of focusing on DNA and proteins in monitoring changes at a single-cell level, as opposed to RNA. This interview took place at Meeting on the Mesa 2021.