ICLE 2022 | Novel approaches in lymphocyte engineering

Elvira D’Ippolito, PhD, Technical University of Munich, Munich, Germany, introduces a poster session that she is chairing at the International Conference on Lymphocyte Engineering (ICLE) 2022 on novel approaches in lymphocyte engineering. In this session, a novel avidity-controlled chimeric antigen receptor (AvidCAR) platform and a nanoparticle-sensitized photoporation approach for the safe engineering of therapeutic cells will be presented. In addition, Dr D’Ippolito describes a novel tumor model in humanized mice for the study of immunotherapy, as well as a study integrating CRISPR-cas9 screening and single-cell RNA sequencing to better understand transcriptional regulators and downstream gene networks in human regulatory T (Treg) cells. This interview took place at ICLE 2022.