Maria-Victoria Mateos, MD, PhD, University of Salamanca, Salamanca, Spain, outlines the practical and patient-related aspects that need to be considered for the implementation of CAR T-cell therapy in multiple myeloma. In order to select the appropriate therapy for each patient, physicians need to consider different criteria, such as disease morbidity, treatment history, organ function, family and social support and quality of life. This interview took place during the 3rd European CAR T-cell Meeting.