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ICLE 2022 | Development and applications of OverCITE-seq

Mateusz Legut, PhD, New York Genome Center, New York, NY, provides an overview of the single-cell genomics method OverCITE-seq and its role in improving next-generation T cell therapies. Initial iterations of single-cell phenotyping technology came in the form CITE-seq, which enabled simultaneous RNA sequencing and measurement of surface protein levels, as well as ECCITE-seq, which utilizes CRISPR screens to assess changes in the transcriptome. OverCITE-seq, the third generation of single-cell genomics technology, measures levels of overexpressed genes and their effect on T-cells. This interview took place at the International Conference on Lymphocyte Engineering (ICLE) 2022.