Giuseppe Orlando, MD, PhD, Wake Forest School of Medicine, Winston-Salem, NC, discusses current developments in organ engineering. Healthy mitochondria can repair damaged kidneys, and decellularization can enable procurement of biomaterials that can regenerate islet cells in the pancreas, or help stem cells differentiate into β cells. This interview took place at the 6th World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS 2021).